Skip to main content
  • Poster Abstract Presentations
  • Open access
  • Published:

P4.4 Doppler Indexes of Left Ventricular Systolic and Diastolic Flows and Central Pulse Pressure in Relation to Renal Resistive Index in a General Population

Abstract

Background

The cardio-renal interaction occurs via hemodynamic and humoral factors. Non-invasive assessment of renal hemodynamics is currently possible by assessment of renal resistive index (RRI) derived from intrarenal Doppler arterial waveforms. So far, only limited information is available regarding the relationship between RRI and cardiac hemodynamics in the general population. We investigated these associations in randomly recruited subjects from a Flemish population.

Methods

In 171 participants (48.5% women; mean age, 52.2 years), using conventional pulsed wave Doppler, we measured RRI (mean, 0.60) and left ventricular outflow tract (LVOT) and transmitral (E and A) blood flow peak velocities and its velocity time integrals (VTI). Using carotid applanation tonometry, we measured central pulse pressure (cPP) and arterial stiffness indexes such as augmentation pressure and carotid-femoral pulse wave velocity.

Result

In stepwise regression analysis, RRI independently and significantly increased with female sex, age, body weight, brachial pulse pressure and use of β-blockers, whereas it decreased with body height and mean arterial pressure. In multivariable-adjusted models with cPP and arterial stiffness indexes as the explanatory variables, we observed a significant and positive correlation of RRI only with cPP (P<0.0001). Among the Doppler indexes of left ventricular blood flow, RRI was significantly and positively associated with LVOT and E peak velocities (P≤0.012) and VTIs (P≤0.010).

Conclusions

We demonstrated that in unselected subjects RRI was significantly associated with cPP and left ventricular systolic and diastolic Doppler blood flow indexes. Our findings imply that in addition to the anthropometric characteristics, cardiac hemodynamic factors influence the intrarenal arterial Doppler waveform patterns.

Author information

Authors and Affiliations

Authors

Rights and permissions

This is an open access article distributed under the CC BY-NC license http://creativecommons.org/licenses/by/4.0/.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Cauwenberghs, N., Knez, J., Thijs, L. et al. P4.4 Doppler Indexes of Left Ventricular Systolic and Diastolic Flows and Central Pulse Pressure in Relation to Renal Resistive Index in a General Population. Artery Res 8, 140 (2014). https://doi.org/10.1016/j.artres.2014.09.127

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1016/j.artres.2014.09.127