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P4.3 Influence of Gender on Aortic Stiffness in COPD

Abstract

Background

Male patients with chronic obstructive pulmonary disease (COPD) are at greater risk of cardiovascular (CV) events than females1.

Aortic stiffness is an independent predictor of adverse CV outcomes and elevated in COPD2. However, the influence of gender on aortic stiffness in COPD has not been established. We hypothesized that males with COPD would have greater aortic stiffness than females.

Methods

As part of the ARCADE study, we assessed 500 patients with COPD confirmed by spirometry and 150 comparators. Aortic pulse wave velocity (PWV) was evaluated using the sphygmoCor device. Other assessments included body composition, blood pressure, heart rate, number of exacerbations, smoking history and C-reactive protein and fibrinogen.

Results

Patients and comparators were similar in age, BMI and gender. Males with COPD (255) had greater aortic PWV mean (SD)10.2 (2.7) than females, 9.5 (2.4), p=0.003. However, they were similar in age, FEV1%, BMI, peripheral and central blood pressure indices, heart rate, number of exacerbations, smoking history and inflammatory biomarkers, p>0.05. The difference remained after controlling for age and peripheral mean arterial pressure (Adjusted R2=26%, F=6.15, p=0.014). The gender difference was not evident in the comparator group.

Conclusion

Males with COPD had greater aortic stiffness compared to the females, independent of traditional cardiovascular risk factors. The increased aortic stiffness may explain the high incidence of fatal and non-fatal cardiac events in the male patients, which may offer a therapeutic target.

References

  1. Agusti et al. 2010. Respir Res. 11:122.

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  2. Vlachopoulos et al. 2010. J Am Coll Cardiol. 55(13):1318–1327.

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This is an open access article distributed under the CC BY-NC license http://creativecommons.org/licenses/by/4.0/.

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Albarrati, A., Gale, N., Munnery, I. et al. P4.3 Influence of Gender on Aortic Stiffness in COPD. Artery Res 8, 139–140 (2014). https://doi.org/10.1016/j.artres.2014.09.126

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  • DOI: https://doi.org/10.1016/j.artres.2014.09.126