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P2.13 Foot to Toe Pulse Wave Velocity with Popmetre® Independently Correlates with Glomerular Filtration Rate in Renal Transplant Patients

Abstract

Aim

To evaluate the relationship between glomerular filtration rate and arterial stiffness using Pulse Wave Velocity (PWV) as an independent cardiovascular risk factor in renal transplanted patients.

Patients and methods

We studied transplanted patients followed in our outpatient clinic. After a medical examination, we measured blood pressure (Comfort Cuff- Skil-Care, USA), PWV (pOpmètre® - Axelife sas - France) after 10 min supine resting. pOpmetre® measures the finger to toe transit time, and according to a height chart, calculates the PWV. Three measurements were performed to study the repeatability. Estimated glomerular filtration rate (eGFR) was calculated using MDRD equation.

Results

Forty-four (30 men, 14 women) renal transplant recipients were included. No significant difference between men and women were found in age (M±SEM: 53.2±2.2 years), systolic blood pressure (SBP: 138±2 mmHg), diastolic blood pressure (DBP: 81 ±2 mmHg), eGFR (45.9±2.4 ml/min/1.73 m2) and PWV (10.4±1 m/s) [range: 6.0–15.7]. Repeatability expressed as the SD/mean of 3 measurements was very good: 5.4%.

PWV correlated positively with age (r2 = 0.16, p<0.009) and negatively with eGFR (r2 = 0.15, p<0.009). Using a stepwise regression model (including gender, age, SBP, DBP, height, weight), only age and pOpmetre PWV remained significantly associated with eGFR.

Conclusions

Glomerular filtration rate independently correlates with pulse wave velocity in renal transplant patients, supporting the hypothesis that kidney function plays a predominant role in arterial stiffness.

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This is an open access article distributed under the CC BY-NC license http://creativecommons.org/licenses/by/4.0/.

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Hallab, M., Bertin, S. & Halimi, J. P2.13 Foot to Toe Pulse Wave Velocity with Popmetre® Independently Correlates with Glomerular Filtration Rate in Renal Transplant Patients. Artery Res 8, 135–136 (2014). https://doi.org/10.1016/j.artres.2014.09.109

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  • DOI: https://doi.org/10.1016/j.artres.2014.09.109