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P2.7 Validation of the Complior® Analyse in the Assessment of Central Artery Pressure Curves and Aortic Pulse Wave Velocity



The purpose of this study was to evaluate the accuracy of carotid pulse wave analysis (PWA) and aortic pulse wave velocity (PWV) with the new version of the Complior device - the Complior Analyse.


Two cross-sectional studies were implemented to address the reproducibility of the device (87 participants, 60% men, with a mean age of 34.26±16.58 years), and its accuracy comparing it with invasive hemodynamic parameters (15 patients, 7 female gender, mean age 62.07±10.59 years, referenced for cardiac catheterization).


The analysis of concordance revealed a very good agreement for paired PWA and PWV values, regarding both the intra- and inter-observer variability. The intra-observer’s intra-class correlation coefficients (ICC) were 0.99 (IC:0.95–1.00, p<0.0001), 0.97 (IC:0.96–0.98, p<0.0001), 0.98 (IC:0.97–0.99, p<0.0001) and 0.86 (IC:0.77–0.90, p<0.0001), respectively for PWV, central systolic (cSBP), pulse pressure (cPP) and augmentation index (AiX). For inter-observer analysis, the ICCs were 0.98 (IC:0.93–0.99, p<0.0001), 0.98 (IC:0.97–0.99, p<0.0001), 0.98 (IC:0.97–0.99, p<0.0001) and 0.85 (IC:0.77–0.89, p<0.0001).

A good concordance between Complior and invasive hemodynamic data was also obtained for all the measured parameters, with intraclass correlation (ICC) coefficients above 0.9. Bland-Altman’s analysis also denoted a good accuracy profile of the Complior device, with small mean differences observed for all parameters and most values confined within 2 standard deviations of the mean difference.


The presented results and available research clearly indicate that the Complior Analyse device measures accurately carotid pressure waves, and has an excellent reproducibility when used in ideal conditions and by experienced observers.

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Pereira, T., Maldonado, J. P2.7 Validation of the Complior® Analyse in the Assessment of Central Artery Pressure Curves and Aortic Pulse Wave Velocity. Artery Res 8, 134 (2014).

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