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P2.3 Subclinical Atherosclerosis and Cardiovascular Risk Factors: Ten Years of Experience with IMT Plus® in the Netherlands

Abstract

Purpose

Atherosclerosis has become a global disease and risk factor mitigation has been a priority in counties like the Netherlands.We assessed the impact of this new approach on cardiovascular subclinical atherosclerosis and cardiovascular risk factors.

Methods

A quantitative standardized sonographic carotid intima media thickness and plaque formation(IMTplus®). IMT plus® distribution was done in accordance with the previously published protocol. (A, being a value lower than the P50, <0.700 mm; B, being a value between P50 and P90, 0,700 and 0,850 mm; C, being a value between P90 and P125, 0,851–0,948 mm; D, being P125 and P200 with values between 0,948 – 1,300 mm and an E, value above P200 >1,300 mm; P means percentile). (Prevention Concepts® Database)

Results

Distribution of IMT Plus® categories in the Netherlands and VS The Netherlands (mean age 53 years, 60 % men) Total number of cases per category:

Total: N = 18.703(100%); A:N = 2685(14,4%); B:N = 6425(34.4%); C:N = 6600(35.3%); D:N = 2372(12,7%); E:N = 571(3.0%).

US (mean age 50 years 49% men) Total number of cases per category:

Total: N = 29.894 (100%); A:N = 6001(15%); B:N = 10403(26%); C:N = 13199(34%); D:N = 7888(19%); E:N = 2403 (3%).

Conclusions

The benchmark of ten years of IMT Plus® results in the Netherlands with the US shows a different picture category A (normal risk), but a greater number of category B (25% increased risk) and a smaller amount of category D (100% increased risk) and category E (200% increased risk) in the Netherlands. The US still leads in the extent and severity of Subclinical Carotid Atherosclerosis but the Netherlands is rapidly catching up. Carotid IMTplus® remains a reliable surrogate to assess atherosclerosis development.

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Barth, J. P2.3 Subclinical Atherosclerosis and Cardiovascular Risk Factors: Ten Years of Experience with IMT Plus® in the Netherlands. Artery Res 8, 133 (2014). https://doi.org/10.1016/j.artres.2014.09.099

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  • DOI: https://doi.org/10.1016/j.artres.2014.09.099