Skip to main content
  • Poster Abstract Presentations
  • Open access
  • Published:

P2.1 Carotid Plaque Microvasculature Assessed Using Dynamic Contrast-Enhanced MRI: Comparing Different Regions of the Vascular Wall

Abstract

Background

Pharmacokinetic modeling in Dynamic Contrast-Enhanced (DCE-)MRI has been introduced to non-invasively assess microvasculature in carotid atherosclerotic plaques, a marker for plaque vulnerability. The main model-parameter, Ktrans, can be assessed in the outer region of the vessel (adventitia) or in the entire vessel wall (including plaque and adventitia) and already showed association with histology and features of plaque vulnerability, respectively. We investigated systematically the correlation between Ktrans of these various regions of the vascular wall and their individual correlation with histology as gold standard.

Methods

45 symptomatic patients with 30–99% carotid stenosis underwent 3T DCE-MRI (0.1mmol/kg Gadobutrol, 0.5ml/sec). Quantitative modeling was performed to determine Ktrans of the entire vessel wall, adventitia, and plaque region, separately. For 10 patients, CD31 immunohistochemistry was performed on specimens (containing mainly plaque) removed during carotid endarterectomy to quantify the endothelial microvessel area.

Results

Adventitial Ktrans showed weak correlation with plaque Ktrans (r=0.64, p<0.001) and was 17.3% higher (p<0.001), coinciding with decreased uncertainty in parameter estimation (p=0.015). Significant positive correlation between the endothelial microvessel area and adventitial Ktrans (r=0.854, p=0.002), but not from the plaque (r=0.438, p=0.2) was observed. Entire vessel wall Ktrans showed intermediate results for the various analyses.

Discussion

Although Ktrans assessed over various regions within the vascular wall are correlated, absolute values differ significantly. Adventitial Ktrans seems to be a better measure for plaque microvasculature compared to other vascular regions, coinciding with a lower uncertainty in parameter estimation. Comparison with histology in a larger number of patients is recommended for definitive conclusions.

Author information

Authors and Affiliations

Authors

Rights and permissions

This is an open access article distributed under the CC BY-NC license http://creativecommons.org/licenses/by/4.0/.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Van Hoof, R., Hermeling, E., Wijnen, N. et al. P2.1 Carotid Plaque Microvasculature Assessed Using Dynamic Contrast-Enhanced MRI: Comparing Different Regions of the Vascular Wall. Artery Res 8, 133 (2014). https://doi.org/10.1016/j.artres.2014.09.097

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1016/j.artres.2014.09.097