Skip to main content
  • Oral Presentation Abstracts
  • Open access
  • Published:

5.7 Aortic Pulse Wave Velocity Increases After 2 Years in Patients with Copd: Data from the Arcade Study

Abstract

Objectives

Patients with COPD have increased risk of cardiovascular (CV) events and mortality beyond that attributable to smoking. However, there have been no longitudinal studies of arterial stiffness in COPD. The Assessment of Risk in Chronic Airways Disease Evaluation (ARCADE) aims to study CV risk factors in COPD and controls, free from respiratory disease, longitudinally. We hypothesised that patients with COPD would have increased Aortic pulse wave velocity (AoPWV) over 2 years.

Methods

At baseline, AoPWV was measured using the SphygmoCor device in 525 patients with COPD and 150 controls. Lung function (Forced expiratory volume in 1 second (FEV1) and Forced vital capacity (FVC)), BMI, blood pressure (BP) and systemic inflammation (HsCRP) was also measured. These were repeated after 2 years.

Results

At baseline, patients and controls were similar in age, gender and BMI, but patients had greater PWV, systolic and mean arterial BP, heart rate and HsCRP (all p<0.05). Thus far 200 patients with COPD have completed the 2 year follow-up assessment. Patients had a mean AoPWV increase of 0.5 m/s (95%CI 0.25–0.71, p<0.001), despite no change in central mean arterial BP. In addition, lung function declined (p<0.05) and HsCRP remained high.

Conclusions

The 2 year AoPWV increase in COPD was independent of traditional risk factors suggesting an alternative mechanism for aortic stiffness in COPD. Further longitudinal assessments of a control group will inform the understanding of the development of arterial stiffness and may indicate possible therapeutic targets.

Author information

Authors and Affiliations

Authors

Rights and permissions

This is an open access article distributed under the CC BY-NC license http://creativecommons.org/licenses/by/4.0/.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gale, N., Albarrati, A., Munnery, M. et al. 5.7 Aortic Pulse Wave Velocity Increases After 2 Years in Patients with Copd: Data from the Arcade Study. Artery Res 8, 129 (2014). https://doi.org/10.1016/j.artres.2014.09.081

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1016/j.artres.2014.09.081