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5.4 Pulse Wave Velocity Distribution in a Cohort Studyefrom Arterial Stiffness to Early Vascular Ageing (EVA)

Abstract

By contrast with other southern European people, north Portuguese population registers an especially high prevalence of hypertension and stroke incidence. We designed a cohort study to identify subjects presenting accelerated and premature arterial ageing in the Portuguese population. Pulse Wave Velocity (PWV) was measured in randomly sampled population dwellers aged 18–96 years from northern Portugal, and used as a marker of early vascular aging (EVA). Of the 3038 subjects enrolled, 2542 completed the evaluation. Mean PWV value for the entire population was 8.4 m/s (men: 8.6 m/s; women: 8.2 m/s; p<0.02). Subjects were classified with EVA if their PWV was ≥ 97.5th percentile of z-score for mean PWV values adjusted for age (using normal European Reference values as comparators). The overall prevalence of EVA was 12.5%; 26.1% of individuals below 30 years presented this feature, and 40.2% of subjects in that same age strata were placed above the 90th percentile of PWV. 18.7% of the population exhibited PWV values above 10 m/s, with male predominance (17.2% of men aged 40–49 years had PWV>10m/s). Logistic regression models indicated gender differences concerning the risk of developing large artery damage, with women having the same odds of PWV>10m/s 10 years later than men. Conclusions: population PWV values were higher than expected in a low CV risk area (Portugal). High prevalence rates of EVA and noteworthy large artery damage in young ages were found.

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Cunha, P., Cotter, J., Oliveira, P. et al. 5.4 Pulse Wave Velocity Distribution in a Cohort Studyefrom Arterial Stiffness to Early Vascular Ageing (EVA). Artery Res 8, 128 (2014). https://doi.org/10.1016/j.artres.2014.09.078

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  • DOI: https://doi.org/10.1016/j.artres.2014.09.078