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3.4 Effect of Vitamin D Supplementation on Aortic Stiffness and Central Haemodynamics in Older Individuals with Vitamin D Deficiency: Promising Observational Data is Not Supported when Tested by Double-Blind, Placebo-Controlled, Randomised Trial Design

Abstract

Background

Observational studies report a relationship between increased aortic stiffness and low vitamin D levels. This suggests that aortic stiffness may be improved with vitamin D supplementation, but there is limited intervention data to support this hypothesis. This study aimed to determine the effect of vitamin D supplementation on aortic stiffness and associated central haemodynamic indices.

Methods

In a double-blind, placebo-controlled trial, 265 individuals (63±7, female 50%) with vitamin D deficiency were randomized to 12-months intervention (vitamin D 50,000 IU/month; n = 132) or matching placebo (n = 133). Aortic stiffness (carotid-femoral pulse wave velocity; aPWV), central haemodynamic indices (augmentation index, augmented pressure, central pulse pressure) and brachial blood pressure were measured at baseline, six and 12 months.

Results

At baseline there were no significant differences between the groups in aPWV (9.0±0.3 vs 9.1±0.2 m/s; P = 0.6), nor any other central hemodynamic indices or brachial blood pressure (all P > 0.05). Intervention failed to make any clinical or statistically significant changes to aPWV (0.16±1.9 vs -0.12±2.2 m/s; P = 0.4), or any other haemodynamic variable relative to control at six or 12 months (all P > 0.05).

Conclusions

Despite many observational studies to suggest that vitamin D supplementation could be a useful therapy for improving aortic stiffness and associated haemodynamic indices, 12-months intervention yielded no improvement in older people with vitamin D deficiency. These results do not support use of vitamin D supplementation to improve cardiovascular health in this patient population.

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Veloudi, P., Ding, C., Blizzard, L. et al. 3.4 Effect of Vitamin D Supplementation on Aortic Stiffness and Central Haemodynamics in Older Individuals with Vitamin D Deficiency: Promising Observational Data is Not Supported when Tested by Double-Blind, Placebo-Controlled, Randomised Trial Design. Artery Res 8, 125–126 (2014). https://doi.org/10.1016/j.artres.2014.09.066

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  • DOI: https://doi.org/10.1016/j.artres.2014.09.066