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1.3 The Association Between Circulating Undecarboxylated Matrix Gla Protein and Arterial Stiffness in General Population

Abstract

Background

Matrix Gla protein (MGP), a natural calcification inhibitor, strongly correlated with the extent of coronary calcification. Vitamin K is the essential cofactor for activation of MGP. We aimed to establish whether there is also any association between dephosphorylated-uncarboxyled isoform of MGP (dp-ucMGP) and pulse wave velocity (PWV) in random sample of general population.

Methods

1003 general population subjects (a subsample of postMONICA study undertaken in 2008) were analyzed in cross-sectional study. Aortic and peripheral PWV were quantified using Sphygmocor device, dp-ucMGP concentrations form frozen samples by ELISA methods using inaKtif pre-commercial kist developed by VitaK (Maastricht, Netherlands)

Results

Aortic, but not peripheral PWV significantly (with p<0.0001) increased among dp-ucMGP quartile. Using multiple logistic regression, subjects in top quartile of dp-ucMGP (≥ 675 pmol/L) shows about two-times higher risk of having high aPWV (≥ 9.3 m/sec) or an absolute increase of PWV by 1 m/sec, even if adjusted for potential covariates (age, history of vascular disease, obesity, raised blood pressure and overt diabetes also entered significantly the regression model).

Conclusion

Increased dp-ucMGP as circulating biomarker of vitamin K status and vascular calcification independently predicts high central-type, large artery stiffness. In contrast, peripheral muscular-type arteries remain uninfluenced. (supported by IGA Ministry of Health, grant nos 12102 and 13186)

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This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by/4.0/).

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Mayer, O., Seidlerová, J., Filipovský, J. et al. 1.3 The Association Between Circulating Undecarboxylated Matrix Gla Protein and Arterial Stiffness in General Population. Artery Res 8, 122 (2014). https://doi.org/10.1016/j.artres.2014.09.052

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  • DOI: https://doi.org/10.1016/j.artres.2014.09.052