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PO-05 Buffering of Carotid Artery Pressure and Flow Pulsatility During Cognitive Engagement in Healthy Adults

Abstract

The matching of vascular supply to neuronal metabolic demand during cognitive engagement is known as neurovascular coupling (NVC). Excessive hemodynamic pulsatility may have a detrimental effect on neural function and affect NVC. Arterial stiffness is a prominent determinant of pulsatility in the brain.1, 2

Objectives

We explored changes in arterial stiffness and cerebrovascular hemodynamic pulsatility during cognitive engagement in healthy adults.

Methods

Twenty-seven adults (age 39 ± 3 yrs, BMI 24±1 kg/m2) underwent Doppler ultrasonography and applanation tonometry of the common carotid artery (CCA) to derive 1) CCA elastic modulus (Ep) and β-stiffness index; 2) CCA flow pulsatility index (PI); 3) CCA pulse pressure (PP), and 4) CCA augmentation index (AIx). Transcranial Doppler was used to assess cerebral PI at the middle cerebral artery (MCA). All measures were made simultaneously at rest and during a 4-minute Stroop task.

Results

CCA PI was reduced (p<0.05) while MCA PI was unchanged (p<0.05) during Stroop. Brachial PP increased during Stroop (p<0.05) while CCA PP was unchanged (p>0.05). Similarly, CCA Ep (p>0.05) and β-stiffness (p>0.05) were unchanged. CCA AIx increased (p<0.05).

Conclusion

Carotid pressure pulsatility and cerebral flow pulsatility is unaltered while carotid flow pulsatility is reduced during cognitive engagement. Carotid stiffness does not change suggesting that factors other than the elastic properties of the vessel moderate cerebrovascular pulsatility during cognitive engagement.

Table 1 Hemodynamic and vascular parameters at rest and during Stroop task.

References

  1. Mitchell GF, van Buchem MA, Sigurdsson S, Gotal JD, Jonsdottir MK, Kjartansson O, Garcia M, Aspelund T, Harris TB, Gudnason V, Launer LJ. Arterial stiffness,pressureandflowpulsatilityandbrainstructureandfunction:Theage, gene/environment susceptibility–reykjavik study. Brain. 2011;134:3398–3407

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  2. Tarumi T, Ayaz Khan M, Liu J, Tseng BM, Parker R, Riley J, Tinajero C, Zhang R. Cerebral hemodynamics in normal aging: Central artery stiffness, wave reflection, and pressure pulsatility. Journal of cerebral blood flow and metabolism. 2014

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Heffernan, K.S., Spartano, N.L., Augustine, J.A. et al. PO-05 Buffering of Carotid Artery Pressure and Flow Pulsatility During Cognitive Engagement in Healthy Adults. Artery Res 8, 167–168 (2014). https://doi.org/10.1016/j.artres.2014.09.011

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  • DOI: https://doi.org/10.1016/j.artres.2014.09.011