P.038 Interrelation Between Dynamics of Changes Endothelium-Dependent Dilatation and Local Rigidity of the Brachial Artery in Patients with Hyperlipideamia on a Background of Reception Statins within 6 Months

Abstract

Aim

To estimate and contrast the marks of a flow-mediated dilatation (FMD) and distensibility coefficient (DC) of the brachial artery in patients with primary hyperlipideamia on a background of statins within 6 months.

Materials and methods

25 patients, age 58 (51;64) years, with drug-controllable hypertensions and not received lipid-lowering therapies at least 4 weeks prior to the beginning of research. Patients accepted the statins (6 months) in dozes which were defined by titration before achievement of target levels of low density lipoprotein.

Results

FMD of the right brachial artery has been increased significantly after 3 and 6 months of therapy. DC and Blood pressure level changes were not significant within 6 months. Positive dynamics of FMD has been noted in 16 patients (64%), among them in 8 person (50%) negative dynamics DC is noted. The correlation analysis has revealed statistically significant negative interrelation between dynamics FMD and DC (r = -0,47; p = 0,043). Significant correlation between marks of FMD and DC it has not been revealed.

Conclusion

Improvement endothelial functions can be accompanied by increase local rigidity the main arteries of muscular type in the early period of therapy of statins in consequence of decrease basal tone and carry of loading on stiffness layers of an arterial wall, which demands the further researches.