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Table 2 Studies utilising nanoindentation to investigate the mechanical properties of non-human aortic tissue

From: Micromechanical and Ultrastructural Properties of Abdominal Aortic Aneurysms

Study, year Subject Tissue Indenter tip Testing regime Main findings
Akhtar et al. 2009 [47] Ferret DTA 10 µm Conospherical Axial direction across full thickness of vessel Linear decrease in E (stiffness) from adventitia (30 MPa) to intima (8 MPa)
Hemmasizadeh et al. 2012 [48] Porcine DTA 10 µm Conical Axial direction across full thickness of vessel, at three levels along DTA Outer half (adventitia) significantly stiffer (70.27 ± 2.47 kPa) than inner half (media) (60.32 ± 1.65 kPa)
Panpho et al. 2016 [49] Ovine Aorta, from root to coeliac axis 100 µm cylindrical flat punch Radial direction on intimal and adventitial surface
Circumferential direction to media
Linear increase in stiffness with distance from heart, which correlates with biochemical changes
Kermani et al. 2017 [50] Porcine DTA 10 µm Conical Performed in 3 orientations; axial and circumferential (across full thickness of vessel) and radial from lumen. Specimens taken from 3 levels along DTA E higher in circumferential than axial direction i.e. tissue demonstrates anisotropy
  1. DTA indicates descending thoracic aorta, E Young’s modulus, G′ shear storage modulus, G″ shear loss modulus, MPa megapascals, kPa kilopascals, µm micrometre