Fig. 4

Panel A depicts a density plot of the effect size distributions for macrovascular (n = 544; skewness = 2.61; kurtosis = 8.27) and microvascular (n = 205; skewness = 2.99; kurtosis = 9.85) endothelial function. Panel B depicts a density plot of the effect size distributions for different measures used to assess endothelial function such as ultrasonography (n = 559, skewness = 2.64, kurtosis = 8.53), plethysmography (n = 98, skewness = 3.23, kurtosis = 12.08), laser doppler (n = 60, skewness = 2.85, kurtosis = 8.39), and other measures (n = 29, skewness = 1.67, kurtosis = 1.74). Cohen’s d values greater than 4.0 were not shown for visualization purposes